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Search for "inhibitors of protein–protein interactions" in Full Text gives 3 result(s) in Beilstein Journal of Organic Chemistry.
The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands
Beilstein J. Org. Chem. 2017, 13, 2842–2853, doi:10.3762/bjoc.13.276
- stabilizer of β-strand mimics. Indeed, β-strand mimics have a particular interest as ligand of β-sheet structures and as potential inhibitors of protein–protein interactions involving β-sheet structures [11][12][13]. For example, β-strand mimics have been successfully introduced in inhibitors of amyloid
- containing trifluoromethylated analogues of threonine as inhibitors of protein–protein interactions involving β-sheet structures. As a proof of concept, we demonstrated that the incorporation of the CF3-Thr residues in hydrophobic pentapeptides allowed their interaction with the amyloid protein Aβ1-42, in
Peptide–polymer ligands for a tandem WW-domain, an adaptive multivalent protein–protein interaction: lessons on the thermodynamic fitness of flexible ligands
Beilstein J. Org. Chem. 2015, 11, 837–847, doi:10.3762/bjoc.11.93
- superior to induce multivalent binding and to increase affinity, while the more flexible and dendritic polymers, pHPMA and hPG are suitable to induce crosslinking upon binding. Keywords: inhibitors of protein–protein interactions; isothermal titration calorimetry; multivalency; peptide–polymer conjugates
Parallel solid-phase synthesis of diaryltriazoles
Beilstein J. Org. Chem. 2012, 8, 1027–1036, doi:10.3762/bjoc.8.115
- potential inhibitors of protein–protein interactions. Results and Discussion Synthesis of azide-functionalized Wang resins Two azide-functionalized resins were prepared for the solid-phase synthesis of diaryl-triazoles. The commercially available 4-(bromomethyl)benzoic acid (5) was converted into azide 6 in
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